Seeking early detection, injury intervention and damage prevention of Long COVID.
Advancing diagnosis, monitoring, and treatment protocols via computational nuerosimulation.
Proactive, responsive and agile, we are unafraid to refocus neurological research priorities and resources to face emerging RNA variant challenges.
Our core research centers on three primary neurological impact concerns – direct infection, neuro autoimmunity, and distal inflammation.
Direct Infection
Researching genetic
material in nervous system tissue including spiked protein evidencing SARS-CoV-2 capability of infecting and replicating directly within the human brain.
Neuro Autoimmunity
Researching evidence of antibody coated brain blood vessels resulting in significant structural damage and brain tissue inflammation.
Distal Inflammation
Researching SARS-CoV-2 attack on the “support cells” of the brain in the reticular formation – those that ensure neurons are able to keep the brain and body functioning.
This branch of our research into post-acute sequelae of Post RNA Virus examines direct brain infection. Via a longitudinal cohort study, we leverage biological systems, neurological function measures, physical neurocognitive performance, and patient-reported outcome methodologies, hierarchical logistic regression modelling and cluster analysis using the K-medoids clustering approach with a focus on pre-clinical outcomes.
Inspecting the mechanisms of the RNA virus intrinsic immune recognition and its initiation of adaptive antiviral immunity. This involves a particular focus on the natural site of the virus’s encounter within the brain’s vascular system, resulting in antibody-coated blood vessels and structural damage. Research mothodolgy includes leveraging blood tests, blood vessel scans, bioinformatics, MRI/MRA imaging, genetic studies, and primary computational simulation as data sources for further analysis.
Here, we conduct cross-sectional research into the neurological manifestations of post-RNA virus infection. We focus on microvascular damage pathology and brain stem immune profiling, as evidenced by bilateral Reticular hyperintensities in MRI/MRA imaging. Research methods include biopsy sampling, 165 ribosomal RNA gene survey, cluster analysis and phenotype-guided analysis.
3D-Printed Brain Tissue
Printed tissue cells developed into functional neurons in a matter of weeks. The approach could be used to repair RNA Virus damage in the brain.
CNS and Mitochondria
Patients suffering from Long COVID exhibit a reduced neurological performance and impaired mitochondrial repair functioning.
COVID Brain Damage
RNA viral associated systemic and CNS inflammation are resulting in brain nerve damage.
Significant JN.1 Variant
As a pathogen JN.1 represents a surprisingly new-look version of SARS-CoV-2 and is rapidly displacing other circulating strains (omicron XBB).
VIRLOGX Chronic Covid Care
Advanced AI-based models applied in Long COVID research saves time, assists clinician care, and improves patient outcomes.
